Therapeutic neuroscience

Fear, avoidance, and getting moving again.

When something hurts, avoiding it is a sensible first reaction. If bending is painful after a strain, you bend less for a few days, and that helps the injury heal. For some people the protection outlasts the injury. Bending, lifting, walking or exercising start to feel dangerous, and avoiding them becomes a way of life. Over months, the avoidance becomes part of the problem.

Reviewed by The Karuna Labs clinical teamUpdated

Does cognitive functional therapy work for chronic low back pain?

Yes, in the largest trial so far. RESTORE randomized 492 adults with chronic, disabling low back pain to cognitive functional therapy or usual care across 20 Australian clinics. Up to seven sessions over 12 weeks cut activity limitation by about 4.6 points on the 24-point Roland Morris scale at 13 weeks, held at one year, and cost society less than usual care.

The therapy works on the fear-avoidance cycle directly: helping people make sense of their pain, challenging the belief that movement is dangerous, and testing that belief through guided movement.

At a glance

Article analysed
Kent, Haines, O'Sullivan and colleagues, The Lancet, June 2023: the RESTORE trial of cognitive functional therapy
Who and where
492 adults with chronic, disabling low back pain, 20 primary care physiotherapy clinics in Australia
Treatment
Up to 7 sessions over 12 weeks of cognitive functional therapy, with or without movement sensor biofeedback, versus usual care
Main result
Activity limitation improved by about 4.6 points on the 24-point Roland Morris Disability Questionnaire at 13 weeks versus usual care
Durability
Similar effects at 52 weeks; three-year follow-up published in 2025
Cost
Less costly than usual care from a societal perspective
The model behind it
The fear-avoidance model (Vlaeyen and Linton): catastrophic interpretation leads to fear, avoidance, deconditioning and disability
What mediates disability
Lee et al., 2015 (12 studies, nearly 3,000 people): self-efficacy, distress and fear each partly explain how pain leads to disability

Key takeaways

  • Avoidance is sensible in the short term and self-defeating in the long term. The fear-avoidance model explains why, and it has held up for more than two decades of testing.
  • Fear, distress and low confidence sit on the pathway from pain to disability. That makes them targets, not side effects.
  • RESTORE is the largest test of a treatment built on these ideas, and it found a clinically meaningful, durable, cheaper-than-usual-care result.
  • The practical method is exposure: rank the feared activities, work through them step by step, and treat each one as an experiment in what actually happens.
  • Fear of movement is a normal response, not a personal failing. Re-engaging with valued activity, ideally with support, is one of the best tested routes out.

What is the fear-avoidance model of pain?

The model was developed largely by Johan Vlaeyen, Steven Linton, Geert Crombez and colleagues. In their 2016 summary they describe how a painful experience can lead in two directions (Vlaeyen et al., 2016). If pain is interpreted as temporary and not especially threatening, people tend to stay active and recover. If it is interpreted catastrophically, as a sign of serious harm, it can trigger pain-related fear. Fear leads to vigilance and avoidance of movement. Avoidance leads to deconditioning, disability, low mood and often more pain, which feeds back into the cycle.

Earlier reviews tracked the evidence for each link in the chain (Vlaeyen and Linton, 2000; Leeuw et al., 2007; Vlaeyen and Linton, 2012), and later work proposed refinements (Crombez et al., 2012). The model is not a complete explanation of chronic pain, and researchers continue to debate its details. But it gives clinicians a practical map: if fear and avoidance are keeping someone stuck, those are things that can be worked on. Our guide to kinesiophobia describes how that fear is measured.

How much does fear explain disability?

A 2015 systematic review looked at mediation studies in people with back and neck pain to ask how pain leads to disability (Lee et al., 2015). Mediation studies examine which factors sit on the pathway between pain and outcomes. Pooling 12 studies with nearly 3,000 participants, the authors found that self-efficacy, psychological distress and fear each partly explained how pain led to disability, while catastrophizing did not reach significance.

The underlying studies were of low methodological quality, which the authors say plainly. Their conclusion still stands as a practical one: these factors are worth targeting directly in treatment, rather than focusing on pain intensity alone.

What is graded exposure for pain?

If fear drives avoidance, one solution borrowed from anxiety treatment is exposure. In graded exposure in vivo, a clinician and patient identify the movements or activities the person fears, rank them from least to most threatening, and work through them step by step. The goal is not to push through pain. It is to test predictions. Someone who expects that bending will damage their back learns, through repeated safe experiences, that it does not.

Randomized trials have tested the approach in chronic low back pain. Leeuw and colleagues compared exposure in vivo with operant graded activity (Leeuw et al., 2008), Woods and Asmundson evaluated graded exposure for pain-related fear (Woods and Asmundson, 2008), and an economic evaluation asked whether exposure was cost-effective (Goossens et al., 2015). Together they establish exposure as a credible option, particularly for people whose fear of movement is high.

What did the RESTORE trial find?

Cognitive functional therapy, or CFT, was developed by Peter O'Sullivan, Peter Kent and colleagues in Australia and combines several of these ideas. It helps people make sense of their pain, challenges unhelpful beliefs, and uses guided movement experiments to build confidence, while also attending to sleep, stress and activity.

The RESTORE trial tested CFT in 492 adults with chronic, disabling low back pain across 20 primary care physiotherapy clinics in Australia (Kent et al., 2023). People received up to seven sessions over 12 weeks. Both CFT alone and CFT with movement sensor biofeedback reduced activity limitation compared with usual care by about 4.6 points on the 24-point Roland Morris Disability Questionnaire at 13 weeks, with similar effects at one year. CFT was also less costly from a societal perspective. Three-year follow-up results have since been published (Hancock et al., 2025).

For scale: the Roland Morris questionnaire runs from 0 to 24, and a change of a few points is generally considered meaningful to the person. A 4.6-point advantage over usual care, holding at a year and costing less, is a strong result for a non-drug, non-surgical treatment delivered in ordinary clinics.

What does breaking the fear-avoidance cycle look like in practice?

For clinicians, the steps are consistent across these approaches:

  • Ask what the person believes is happening in their body, and what they fear will happen if they move.
  • Explain pain in a way that lowers threat, drawing on pain neuroscience education.
  • Build a hierarchy of feared activities and work through it together.
  • Frame each step as an experiment: what do you predict, and what actually happened?
  • Measure function and confidence, not only pain scores.

For people living with pain, it may help to know that fear is a normal response and not a personal failing. Gradually re-engaging with the activities you value, ideally with someone alongside you, is one of the best tested routes out of the cycle. Karuna's program applies the same sequence: understand first, then move in graded steps, with a coach each week. See how it works.

Frequently asked questions

What is cognitive functional therapy?

Cognitive functional therapy (CFT) is a physiotherapist-delivered approach for persistent low back pain that combines making sense of the pain, challenging unhelpful beliefs, guided movement experiments to rebuild confidence, and attention to lifestyle factors such as sleep and stress. It was developed by Peter O'Sullivan, Peter Kent and colleagues in Australia.

How is CFT different from ordinary physiotherapy?

Ordinary care for back pain often centers on exercises, manual therapy or advice. CFT starts with the person's story and beliefs, then uses movement as a way to test and change those beliefs rather than as a strengthening program alone. In RESTORE it was delivered in up to seven sessions over 12 weeks and outperformed usual care on activity limitation.

Is avoiding movement bad for back pain?

In the first days after an injury, some protection is normal and useful. Beyond that, avoidance tends to maintain pain and disability: muscles decondition, confidence drops, and the nervous system learns that movement is dangerous. For nonspecific chronic low back pain, graded movement is the most consistently supported treatment. If you have red-flag symptoms, get evaluated first; see our low back pain page.

What is the Roland Morris Disability Questionnaire?

A 24-item questionnaire about how back pain limits everyday activities, such as walking, dressing and sleeping. Each item scores one point, so 24 is maximal limitation. RESTORE's main result was a 4.6-point improvement relative to usual care at 13 weeks. Our guide to the Oswestry Disability Index covers a related measure.

Does graded exposure mean pushing through pain?

No. Graded exposure means approaching feared activities in small, planned steps so that the nervous system can learn they are safe. Some discomfort during activity is expected and is not a sign of harm, but the steps are chosen to be manageable rather than forced. The point is to test a prediction, not to endure.

Sources & research.

  1. Kent P, Haines T, O'Sullivan P, et al. Cognitive functional therapy with or without movement sensor biofeedback versus usual care for chronic, disabling low back pain (RESTORE): a randomised, controlled, three-arm, parallel group, phase 3, clinical trial. Lancet. 2023;401(10391):1866-1877. PMID 37146623
  2. Hancock M, et al. Cognitive functional therapy for chronic disabling low back pain: 3-year follow-up of the RESTORE trial. Lancet Rheumatol. 2025. PMID 40780241
  3. Vlaeyen JWS, Crombez G, Linton SJ. The fear-avoidance model of pain. Pain. 2016;157(8):1588-1589. PMID 27428892
  4. Vlaeyen JWS, Linton SJ. Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Pain. 2000;85(3):317-332. PMID 10781906
  5. Leeuw M, Goossens ME, Linton SJ, et al. The fear-avoidance model of musculoskeletal pain: current state of scientific evidence. J Behav Med. 2007;30(1):77-94. PMID 17180640
  6. Vlaeyen JWS, Linton SJ. Fear-avoidance model of chronic musculoskeletal pain: 12 years on. Pain. 2012;153(6):1144-1147. PMID 22321917
  7. Crombez G, Eccleston C, Van Damme S, Vlaeyen JWS, Karoly P. Fear-avoidance model of chronic pain: the next generation. Clin J Pain. 2012;28(6):475-483. PMID 22673479
  8. Lee H, Hübscher M, Moseley GL, et al. How does pain lead to disability? A systematic review and meta-analysis of mediation studies in people with back and neck pain. Pain. 2015;156(6):988-997. PMID 25760473
  9. Leeuw M, Goossens ME, van Breukelen GJ, et al. Exposure in vivo versus operant graded activity in chronic low back pain patients: results of a randomized controlled trial. Pain. 2008;138(1):192-207. PMID 18242858
  10. Woods MP, Asmundson GJG. Evaluating the efficacy of graded in vivo exposure for the treatment of fear in patients with chronic back pain: a randomized controlled clinical trial. Pain. 2008;136(3):271-280. PMID 17716819
  11. Goossens ME, de Kinderen RJ, Leeuw M, et al. Is exposure in vivo cost-effective for chronic low back pain? A trial-based economic evaluation. BMC Health Serv Res. 2015;15:549. PMID 26651828

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